A Johns Hopkins team has published landmark results showing that virtual replicas of individual patients’ hearts — so-called “digital twins” — can guide life-saving cardiac procedures with remarkable precision. The findings, reported April 1, 2026 in the New England Journal of Medicine, represent one of the first clinical trials of Read more
Researchers in the Trayanova Lab at Johns Hopkins University, led by ADVANCE member Dr. Natalia Trayanova, as well as ADVANCE members from the Johns Hopkins School of Medicine and other collaborators, have developed a new AI tool that significantly improves prediction of sudden cardiac death in patients with hypertrophic cardiomyopathy. Read more
ADVANCE proudly announces that Natalia Trayanova, Murray B. Sachs Professor of Biomedical Engineering and a global leader in computational cardiology, has been elected to the Board of Trustees of the Heart Rhythm Society—the premier professional organization for more than 9,000 specialists in cardiac rhythm disorders across 90 countries. Trayanova, already Read more
Several members of ADVANCE at Johns Hopkins, as well as collaborators at other institutions, have published DIMON (Diffeomorphic Mapping Operator Learning), an AI framework, in Nature Computational Science. This model accelerates the approximation of partial differential equations (PDEs) in complex engineering problems by thousands of times, enabling personal computers to Read more
JHU Selects ADVANCE ECG Deep Learning Project for Discovery Award Johns Hopkins University’s Discovery Awards encourage faculty from various disciplines to collaborate in addressing multifaceted challenges and pushing the boundaries of understanding. In 2024, 44 Discovery Awards were given to interdisciplinary faculty teams, chosen from 286 proposals. The ADVANCE proposal, entitled Read more
Trayanova Lab Publishes Precision Ablation Study in Nature Cardiovascular Research The Trayanova Lab at Johns Hopkins University is excited to announce the publication of our latest research in Nature Cardiovascular Research, “Assessing the arrhythmogenic propensity of fibrotic substrate using digital twins to inform a mechanisms-based atrial fibrillation ablation strategy,” (direct Read more
Trayanova Lab’s and JHMI Digital Twin Research Featured in Wall Street Journal On March 16th, the Wall Street Journal featured Dr. Trayanova and her lab’s work with JHMI on “digital twins” of people’s hearts– a method of creating a patient-specific model to study electrical problems and potentially guide therapy in a clinical environment. Read more
Baltimore, MD, Feb 12, 2024 – The Alliance for Cardiovascular Diagnostic and Treatment Innovation (ADVANCE) at Johns Hopkins University proudly announces that co-director Professor Natalia Trayanova has been awarded the esteemed Hodgkin-Huxley-Katz Prize Lecture for 2025 by The Physiological Society. This prestigious accolade honors Prof. Trayanova’s groundbreaking contributions to cardiovascular Read more
A multidisciplinary team of computational and clinical researchers from Johns Hopkins University, led by Yingnan Zhang, a Ph.D. candidate at Trayanova Lab, has made significant strides in cardiac research through the development of an innovative strategy called the “genotype-specific digital twin” (Geno-DT). This cutting-edge approach involves integrating personal genetics into Read more
